Alarmins and Antitumor Immunity

Catechins and antitumor immunity

Numerous laboratory and clinical studies have reported that the green tea catechin extract Polyphenon E exert anticancer activity, but the underlying mechanism of action was elusive. We have recently shown that Polyphenon E exerts antineoplastic effects by antagonizing tumor-induced myeloid derived suppressor cells (MDSCs).

Induction of Protective Antitumor Immunity

Polyamine blockade promotes antitumor immunity

The levels of polyamines are elevated in neoplastic lesions as compared with normal tissues, and cancer cells tend to manifest a robust dependence on these compounds for proliferation and survival. We have recently demonstrated that a novel approach to polyamine depletion suppresses tumor growth in a T cell-dependent manner, highlighting a poorly appreciated role of polyamines as strong modulat...

sion and Promotes Protective Antitumor Immunity

ownload or-associated immunosuppressive strategies, such as lack of tumor antigen recognition and failure phocyte activation and homing, resist the development of tumor-specific immunity and hamper the ne response–mediated elimination of cancerous cells. In this report, we show that reovirus virotherverrides such a tumor immune evasion and establishes clinically meaningful antitumor immunity le...

Tumor reductive therapies and antitumor immunity

Tumor reductive therapy is to reduce tumor burden through direct killing of tumor cells. So far, there is no report on the connection between antitumor immunity and tumor reductive therapies. In the last few years, a new category of cancer treatment, immunotherapy, emerged and they are categorized separately from classic cytotoxic treatments (chemo and radiation therapy). The most prominent exa...